The article “First evaluation of QuantiFERON-TB Gold Plus performance in contact screening” evaluated for the first time the performance of a new type of interferon-γ release assay, QuantiFERON-TB Plus (QFT-Plus), which includes an additional antigen tube (TB2), stimulating both CD4+ and CD8+ T-cells in contacts of TB patients.
In 119 TB contacts, the overall agreement between QFT-Plus and QFT-GIT was high. Discordant results were found in 12 subjects with negative QFT-GIT and positive QFT-Plus results.
QFT-Plus has a stronger association with surrogate measures of TB exposure than QFT-GIT in adults screened for latent TB infection. Interferon-γ response in the new antigen tube used an indirect estimate of specific CD8+ response correlates with increased Mycobacterium tuberculosis exposure, suggesting a possible role in identifying individuals with recent infection
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- Barcellini, L., Borroni, E., Brown, J., Brunetti, E., Campisi, D., Castellotti, P.F., Codecasa, L.R., Cugnata, F., Di Serio, C., Ferrarese, M. and Goletti, D., 2016. First evaluation of QuantiFERON-TB Gold Plus performance in contact screening. European Respiratory Journal, pp.ERJ-00510.