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Dr James Brown co-authors paper on new type of IGRA

Congratulations to North East Thames trainee Dr James Brown who has co-authored a paper with Dr Marc Lipman and others in the European Respiratory Journal.

The article “First evaluation of QuantiFERON-TB Gold Plus performance in contact screening” evaluated for the first time the performance of a new type of interferon-γ release assay, QuantiFERON-TB Plus (QFT-Plus), which includes an additional antigen tube (TB2), stimulating both CD4+ and CD8+ T-cells in contacts of TB patients.


In 119 TB contacts, the overall agreement between QFT-Plus and QFT-GIT was high. Discordant results were found in 12 subjects with negative QFT-GIT and positive QFT-Plus results.

QFT-Plus has a stronger association with surrogate measures of TB exposure than QFT-GIT in adults screened for latent TB infection. Interferon-γ response in the new antigen tube used an indirect estimate of specific CD8+ response correlates with increased Mycobacterium tuberculosis exposure, suggesting a possible role in identifying individuals with recent infection

For more, read the full text article here:


One thought on “Dr James Brown co-authors paper on new type of IGRA

  1. Well done James

    Posted by Aarash | August 15, 2016, 1:27 pm

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